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17,123 The phenotype of the disease represents the observable characteristics of the disease or patient (such as obstructive sleep apnea in the elderly, men, or Black patients), whereas the endotype refers to the underlying biological mechanisms which drive disease (such as fat distribution, hyporesponsive muscles of the airway, or abnormal craniofacial structures)

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Enhancement of endogenous defenses against ROS by supra-nutritional level of selenium is more safe and effective than antioxidant supplementation in reducing hypertensive target organ damage