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M1 microglia release cytokines such as CCL2, CXCL10, TNF-, IL-1, and IL-6, which lead to a decreased expression of TJs in blood vessels [203,204,205,206]

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Metabolomic studies have revealed CKD patients show dysregulation in various biochemical pathways like amino acids, lipids, nucleotides, and glycoses [8]

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