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Nonclinical Toxicology 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility Carcinogenesis No evidence of carcinogenic potential was observed in rats or mice administered alprazolam for 2 years at doses up to 30 and 10 mg/kg day respectively

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Patients suffering from diarrhea and constipation may become orthostatic due to medication-mediated volume losses per rectum and warrant a thorough examination and workup prior to surgery

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