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Hypobaric hypoxia is a stress experienced at high altitudes

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Overproduction of reactive oxygen and nitrogen species (ROS and RNS, respectively) is the principal cause of oxidative stress, characterized by an imbalance between antioxidants and pro-oxidants

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However, it is noteworthy that excessive selenium intake can also cause selenosis 29,30 , which accompanies adverse symptoms including fatigue, diarrhea, nausea, increased heart rate, necrosis in liver and kidney, and neurological damage

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