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110 Despite having a large sample size, the database lacked detailed patient information on lifestyle, physical, psychiatric, and laboratory examinations

Losing a significant amount of weighttypically more than 10kgcan make other medications more effective

Stress increases ethanol self-administration via a shift toward excitatory GABA signaling in the ventral tegmental area

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Published trials are sparse, but a 2023 observational study reported modest additional weight loss (35 lbs over 12 weeks) with combination therapy versus single-agent, though nausea and dizziness occurred in 34% of patients