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These diverse phenotypes show the central role of organelle-specific zinc transport in maintaining ER proteostasis, tissue integrity and cellular resilience across multiple disease contexts

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It is class-wide counter-regulation: stopping removes the signal that was holding down a set-point the body still defends. The felt marker of the rebound is the return of food noise, which patients in the exit interviews reported as the first sign the loss was reversing. Metabolic loss tracks weight regain

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