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I don't recommend it for patients, although some of my patients have tried it and said it really helped them

For patients managing diabetes with insulin or sulfonylureas alongside GLP-1 therapy, hypoglycemia becomes a concern

Hyperghrelinemia in Prader-Willi syndrome begins in early infancy long before the onset of hyperphagia

If youre taking a GLP-1 medication for weight loss or diabetes management, youve probably heard about some of the side effectslike fatigue or loss of muscle mass

Genetic or pharmacological inhibition of DRP1 potently abolished SLC39A1-induced mitochondrial division and MMP depolarization, while overexpression DRP1 can reverse SLC39A1 silence induced mitochondrial fusion and hyperpolarization MMP, accompanied by recuperative cell proliferation

Clinical studies support this use: A meta-analysis of bupropion for adult ADHD found significant symptom reduction compared to placebo in participants, making it a reasonable alternative for those who cannot take stimulants (Verbeeck et al., 2017, CNS Drugs)