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Together, these findings support a role for ABHD11 in controlling CD8 + T cell differentiation, with implications for 2-OG metabolism and oxygen tensions in contributing to the phenotypic differences between T cell states (Fig
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To alter the binding pocket of Peredox to favour NADP binding, we introduced mutations known to switch the specificity of the Rex domain from favouring NADH binding to favouring NADPH 15 and generated combinatorial mutants thereof
