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Strengthens the skin barrier to prevent moisture loss
In particular, upon administration in mice, only the mono-glutathionylated adducts were not toxic to kidneys, while a correlation was recorded between the number of glutathione substitutions and the nephrotoxicity observed [83]
[DOI] [PMC free article] [PubMed] [Google Scholar] 105.World Health Organization
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Publicly available datasets reported in this paper are from the GEO databases (GSE13911, GSE27342, and GSE13861) and The Cancer Genome Atlas
However, outcome from investigations using mice genetically manipulated for proteins integral or associated with the TJ have not been consistent and have resulted in diverse effects including immune adaptation and tolerance (summarized in Table 2)
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