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Ozempic, Wegovy, and other semaglutide-based prescription medications are being prescribed for weight loss if the patient is clinically obese

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In animal TLE models, HMGB1 acts through TLR-4 to increase production of cytokines such as IL-1, TNF, and IL-6 ( Tumor necrosis factor alpha (TNF) further impacts the oxidative environment and metabolism in the brain by targeting mitochondria

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