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This happens remarkably fast: Within seconds: DPP-4 begins degrading GLP-1 as soon as it enters circulation 1-2 minute half-life: 50% of secreted GLP-1 is inactivated within 2 minutes Near-complete degradation: 80-90% of GLP-1 is broken down within 5 minutes This rapid degradation means that even if your L-cells produce abundant GLP-1, the hormones metabolic effects are limited by how quickly DPP-4 eliminates it from circulation