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Companies have requested and received pediatric exclusivity extensions for cardiac drugs, erectile dysfunction medications, and antihypertensives, categories where pediatric use is minimal

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This growth has had ripple effects on common comorbid conditions associated with diabetes and obesity, including hypertension, high cholesterol, and gastroesophageal reflux disease (GERD)

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If tolerated, increase in 500 mg increments up to 2 to 3 grams per day if a clinician agrees