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Prepubertal children with obesity have high free IGF-1 levels and accelerated growth despite reduced Pappalysin levels
The exact mechanism is not fully understood, but it may involve slowed gastric emptying and increased satiety through effects on central appetite centres in the brain
Distribution of angiotensin IV binding sites (AT4 receptor) in the human forebrain, midbrain and pons as visualised by in vitro receptor autoradiography
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By integrating current evidence, we seek to inform clinical practice, guide public health messaging, and identify key areas where further research and regulation are warranted
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