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In vitro , liraglutide dose-dependently downregulates pro-inflammatory mediators such as Mcp-1 and Cd38 in LPS-activated RAW264.7 macrophages, while simultaneously upregulating Erg-2, an M2-specific transcription factor (Yu et al., 2019)

At the same time, average total payments per patient which included out-of-pocket costs as well as payments from private insurers, employers and government programs increased 157% for adults without diabetes and 36% for those with diabetes

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