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Individual responses vary considerably, and not everyone achieves the average weight loss seen in clinical trials

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Canagliflozin significantly inhibits inflammatory factor expression, including cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase, exerting cardioprotective effects by regulating inflammation and ferroptosis through the AMP-activated protein kinase (AMPK) pathway (83)

However, there was no increase in suicidal behavior, attempts, or completed suicide vs

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