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Since the distributions of GLP-1R in sino-atrial node and ventricular cardiomyocytes [31, 38], a previous study indicated that the direct activations of GLP-1R effectively opposed the effects of -adrenoceptor stimulation on cardiac ventricular excitability and might be responsible for HR augmentation or arrhythmias [39]

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Minimum fluid target: 64 ounces daily, more in hot climates or with regular exercise

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