HUVECs grown in the 3D model exhibited not only a markedly elevated level of oxidative stress, expressed by an increased level of malondialdehyde and superoxide dismutase activity inhibition, but also an increased inflammatory response with more secretion of IL-1 and IL-6 in response to TNF- when compared to ECs grown on 2D TCPs
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Given these limitations of weight-based dosing and the demonstrated superiority of personalized approaches, therapeutic drug monitoring (TDM) is recommended as the standard of care for optimizing individual regimens (Palmer et al., 2016)
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