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In order to reduce hydrolysis and/or degradation of the therapeutic agent during sterilization, the buffer pH is designed to maintain pH of the formulation or composition in the 7-8 range during the process of sterilization

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The entire area within this oval (except the two-inch exclusion zone around the navel) is fair game

As a result, the total mass of an empty two-liter bottle was up to 96 gramsexactly double that of modern two-liter bottles

[DOI] [PubMed] [Google Scholar] 111.Layman DK, Shiue H, Sather C, Erickson DJ, Baum J