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Ive noticed that patients with more structured eating routines tend to do better with either medication

"Structural and mechanistic studies on -butyrobetaine hydroxylase"

In This Article: Why High Cortisol Affects Women Differently Physical Symptoms of High Cortisol in Women Metabolic and Weight-Related Symptoms The Wired but Tired Pattern Emotional and Cognitive Symptoms Hormonal and Reproductive Symptoms Muscle Weakness and Physical Decline When to See a Healthcare Provider Why High Cortisol Affects Women Differently Hormonal fluctuations across the menstrual cycle, perimenopause, and menopause can influence how the body produces, responds to, and regulates cortisoloften referred to as the stress hormonewhich may make some women more sensitive to the effects of high levels

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This happens because certain MTHFR mutations (C667T and A129C) lower the amount of active folate being produced in the body, and the use of vitamin B12 requires the active form of folate