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A comprehensive review of citrulline malate supplementation indicates that while acute performance benefits vary between studies, the amino acid consistently supports exercise capacity through enhanced nitric oxide-mediated blood flow [6]

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Paper Notes Limitations This was an observational study, meaning it cannot definitively prove cause and effect

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Commenters recommended assigning status indicator S and place these codes in appropriate APCs to reflect the clinical complexity and resource intensity of these services

It can be concluded that the dopaminergic deficit is efficiently compensated for a long period of time, at least 10 years or longer, during the normal or near-normal motor activity (silent/prodromal motor period) before clinical symptoms are sufficient for diagnosis (manifested period) [41]