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aOoC models have been predominantly applied in cancer research, as tumors are relatively accessible for biopsy, providing the isolation of patient-specific cells (156)

Furthermore, it is contraindicated in dialysis patients due to the potential increase in TMAO production

HbA1C levels play a role too - each 1% increase leads to a 36% higher risk [3]

Essentially, it mimics what happens during exercise at the cellular level