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The fluorescence of A was significantly lower in GO + amlodipine (36%), GO + aminoguanidine (36%), and GO + NAC (49%) than in GO

The mutations in certain genes such as PTEN , fragile X mental retardation 1 ( FMR1 ), chromodomain helicase DNA binding protein 7 ( CHD7 ), and tuberous sclerosis 1 and 2 ( TSC1 and TSC2 ) are associated with the ASD [208,209,210,211,212]

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Rather than developing more potent GLP-1 agonists or adding more receptor targets (dual, triple agonists), the amylin pathway offers a truly paired mechanism