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Interestingly, metabolic disorders such as obesity and type 2 diabetes substantially increase dementia risk, suggesting that metabolic signals may modulate neuroinflammatory processes 5

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Glucagon-like peptide-1 receptor agonist exendin-4 mitigates lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages

Some cardiovascular drugs have also shown potential antidiabetes effects

Neuroinflammation also plays a major role, with microglial cells releasing inflammatory molecules such as TNF-, IL-6, and IL-1, along with ROS, all of which intensify neuronal damage (Liu and Wang, 2017)