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188 These findings suggest that CTSB inhibitors may act on both acinar cells and macrophage-driven inflammation and that dual-targeted strategies focusing on CTSB and its downstream signaling (e.g., NF-B) may offer a more comprehensive approach to treatment

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For patients without coverage, Eli Lilly has periodically offered cash-pay discount programs, though availability and terms change frequently

The collected supernatants were spun at 13,300 rpm for 10 min at 4 C and subsequently subjected to vacuum freeze-drying

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Participants were randomized to placebo or retatrutide at 1 mg, 4 mg (dose-escalation), 4 mg (no escalation), 8 mg (escalation), 8 mg (no escalation), or 12 mg (escalation) for 48 weeks, following a slow titration protocol