The American Journal of Gastroenterology, 113 (1), 115123
This is because tirzepatide is designed to mimic the action of two gut hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which are released in response to food intake and help to regulate blood sugar levels
Freezing causes ice crystal formation that can physically damage the peptide structure, creating aggregates that reduce bioavailability and may trigger injection site reactions
Regular Check-ups: Regular visits to your healthcare provider will allow them to monitor any potential side effects and make adjustments to your treatment plan if necessary
Rotating injection sites between abdomen, thigh, and upper arm prevents lipohypertrophy and maintains consistent absorption
Because it's a temperature-sensitive injectable, many people are understandably concerned about what happens if it's stored improperly, especially in extreme cold or warm temperatures