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Keywords: insulin-like growth factor-1, chondrocyte, cartilage development, osteoarthritis, rabbit Introduction Osteoarthritis (OA) is a disorder characterized by joint pain and disability that is associated with deterioration in quality of life

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Further investigations have revealed that activated ErbB2 stimulates the expression of GLS in cancer cells through the PI3K/Akt-independent nuclear factor-kappa B (NF-kB) pathway in breast and gastric cancer [103, 104]

The biological activity of these NPs depends largely on their size, surface characteristics, and chemical composition, which influence their reactivity and interactions with biological tissues 29

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