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Key Takeaways: The FDA approved the first oral GLP-1 pill for weight loss (Wegovy pill, 25 mg) on December 22, 2025

The development of more effective and targeted medicinal treatments will benefit from additional study to completely understand the mechanisms of action of bioactive peptides

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In 2017, semaglutide (Ozempic) was approved for T2DM treatment, demonstrating enhanced efficacy in both glycemic control and weight loss compared to earlier GLP-1-RAs [31]

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