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Clinical trials, including the SURMOUNT-5 study, demonstrate tirzepatides ability to achieve 13.7-20.2% weight loss in individuals with obesity but without type 2 diabetes, outperforming other GLP-1 receptor agonists in direct comparisons

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Activation of the GLP-1R in pancreatic beta cells results in insulin synthesis, potentiation of glucose-stimulated insulin secretion (GSIS), and longer-term effects on beta cell survival, proliferation and neogenesis

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