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As for the Selection of the reported result (D5) domain, three studies were identified with some concerns (41, 50, 51)

Always consult your healthcare provider for personalized advice and treatment options if you notice significant skin changes

British Journal of Sports Medicine, 36 (4), 282-289

doi: 10.1038/s41596-023-00930-8

Because skin cells take approximately four weeks to regenerate, most people begin to see changes after 4 to 8 weeks of consistent use