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GLP-2s effect predominantly resonates in the gut and the protein does not seem to directly affect glucose levels [14]
Robert Kushner: Well, we're targeting a sweet spot in our biology, Mike, that we didn't really know was there, at least I didn't know what was there
Trial evidence supports significant reductions in body weight and waist circumference, both of which reflect fat loss
International expert consensus published in Obesity Pillars (Sievenpiper et al., 2025) recommends prioritizing protein to preserve muscle mass during rapid weight loss, alongside careful attention to fiber, hydration, and micronutrients
Tirzepatide already slows gastric emptying as part of its mechanism, meaning combining these effects could intensify nausea, constipation, or other gastrointestinal side effects in some patients
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