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For this reason, research protocols have excluded subjects with: Uncontrolled hypertension Established cardiovascular disease History of myocardial infarction or stroke The cardiovascular monitoring protocol used in FDA approval trials required blood pressure measurement before and after administration, establishing a safety baseline that researchers in any context should consider

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275 A key hallmark of AD is disrupted proteostasis, which leads to the pathological buildup of misfolded and aggregated proteins

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