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Cellular studies have shown that exogenous NAD + can impact mitochondrial activity, such as boosting Krebs cycle and the ETC, but also impair genomic DNA replication and induce DNA replication stress due to impairment of pyrimidine biosynthesis 118

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Walk the patient through the forms section describing how B-12 supports energy metabolism, neurological function, and red blood cell formation

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2012 Dec;59(3):673-8