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9 The GLP-1RA (glucagon-like peptide-1 receptor agonist), semaglutide, is approved at a dose of 2.4 mg once weekly, administered subcutaneously, for long-term weight management and cardiovascular risk reduction

Guan, J., Kinoshita, M

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However, this function can be compromised during copper overload, as Cu binding to the cysteine residues of GPX4 promotes its ubiquitination and autophagic degradation, thereby disrupting lipid peroxide metabolism and sensitizing cells to ferroptosis [65]

Recent studies have highlighted an overactivation of this pathway in several human cancers [104]

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