The split-dosing approach (3x weekly vs once weekly) is described as maintaining more consistent hormone levels and reducing peak-related side effects
The absorption technology needed to make oral GLP-1 medications work is proprietary and patented
Same total
Nutr Metab Cardiovasc Dis 32(4):770814 Davies MJ, Aroda VR, Collins BS, Gabbay RA, Green J, Maruthur NM, Rosas SE, Del Prato S, Mathieu C, Mingrone G, Rossing P, Tankova T, Tsapas A, Buse JB (2022) Management of hyperglycaemia in type 2 diabetes, 2022
Whilst preliminary research suggests berberine may modestly reduce fasting glucose and HbA1c levels through mechanisms including AMPK activation and improved insulin sensitivity, it remains an unlicensed food supplement in the UK
The question at this stage is whether the incremental benefit over 12.5mg justifies the increased side effect burden