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These typically include: Body Mass Index (BMI): A BMI of 30 kg/m or greater (considered obese)

This data, expected in 2026, will clarify whether lower maintenance doses are viable for long-term weight management after initial weight loss is achieved

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The success of G12C inhibitors fundamentally changed the perception of KRAS from an "undruggable" target to a clinically actionable oncogenic driver and established the foundation for subsequent KRAS-targeted drug development

ItoMTakamoriAYonedaSShiozakiATsuchidaAMatsumuraKet al (2019)