Specifically, mitochondrial complex I is believed to be the main component of mitochondria affected in PD as Complex I of the electron transport chain is left vulnerable to oxidative damage (Vali et al., 2007)
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Furthermore, the autophagy receptor FUNDC1 has been shown to induce mitochondrial fragmentation, in addition to its involvement in the essential role of mitophagy (Dirks-Naylor et al., 2014)
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In the SURMOUNT-1 trial, tirzepatide produced average weight loss of 15-22.5% of body weight over 72 weeks depending on dose
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