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Available from: Accessed: 10 Jun 2025 European Medicines Agency (2023) Guideline on clinical investigation of medicinal products in the treatment or prevention of diabetes mellitus

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Greater Weight Loss Clinical Trial Data: In the Phase 2 TRIUMPH-1 study , retatrutide achieved unprecedented levels of weight loss : Up to 24.2% average total body weight loss at 48 weeks Over 26% weight loss at the highest dose (12 mg weekly) In comparison: Tirzepatides weight loss peaked at about 22.5% in SURMOUNT-1 at 72 weeks This suggests faster, more significant fat loss in less time with retatrutide

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J Biol Chem 289:2705527064 Engel K, Zhou M, Wang J (2004) Identification and characterization of a novel monoamine transporter in the human brain

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