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The RIPENACTB trial reported that 1,200 mg BID NAC was safe in HIV-positive TB patients, though it did not show a significant impact on sputum conversion rate (73)

development halted at Phase 2 in the late 1990s due to safety profile Reference sources (PubMed) Dorr RT

Data availability The data that support the findings of this study are available within the paper and its Supplementary Information or from the corresponding authors upon request

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Role of mast cells Mast cells and macrophages act by releasing interleukins (IL-1, IL-6, IL-12, IL-15, IL-18, IL-23), TNF-, reactive nitrogen and oxygen species, phagocytosis and antigen presentation, production of matrix-degrading enzymes and prostanoids (Shichita et al