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Notably, after oral administration of CRCR, multiple active componentsincluding senkyunolide Awere detected in the serum and cerebral cortex of rats, suggesting that senkyunolide A may be one of the key bioactive components underlying the anti-migraine efficacy of CRCR ( Gastrodia elata )
Support for this notion comes from instructive pathological feature found at the other end of the temporal spectrum, the so-called pre-active lesion, consisting of small clusters of activated microglia seen throughout the MS NAWM, accompanied by axonal and oligodendroglial injury (van Noort et al., 2011
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