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However, a randomized double-blind placebo controlled trial revealed that GPR119 agonism was not as effective at increasing total and active GLP-1 responses to glucose or a mixed liquid meal nor was it as effective at improving glucose control over a 2-week study period (116)
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The oxidative stress, antioxidant, and neurochemical parameters, viz., malondialdehyde (MDA), nitric oxide (NO), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), acetylcholine esterase (AchE), dopamine (DA), norepinephrine (NE), and serotonin (5-HT), in the hippocampal and hypothalamic regions have been evaluated
In this randomized, double-blind trial, an unadjusted 6-month comparison showed higher HbA1c in the CA group than in placebo (p = 0.006)
a 39-year-old woman with redness, visible blood vessels, and small bumps on her forehead, cheeks, and chin for a year
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