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AGEs may cause vascular dysfunction by making cross-bonds between extracellular matrix proteins (elastin and collagen), which leads to blood vessel stiffness, heart fibrosis, and diastolic dysfunction 12

10.1177/1933719115612133 22 HarrisM

Many types of PCD have been identified, most of which, such as apoptosis, pyroptosis, PANoptosis, necroptosis, ferroptosis, and cuproptosis could induce or exacerbate OA

Chem Biol Drug Des 2013

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