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We also observed significant correlation between the PANSS general score ( P =0.035) and total GSH level within the BP patient population

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These findings suggest that high baseline autophagic activity, particularly when coupled with elevated checkpoint expression, could serve as a biomarker for identifying patients who may benefit from combining autophagy inhibitors with immunotherapy, a hypothesis awaiting robust clinical validation

Having established the general scope of biomarkers, we next consider their functional classification

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More recently, it also received FDA approval to help reduce the risk of severe heart problems, kidney disease progression, kidney failure, and cardiovascular-related death in certain populations