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In particular, androgens have direct effect on the growth plate in stimulating longitudinal growth, and estrogens (derived from androgen aromatization) lead to epiphysis fusion [35]

however, structural comparison of TYRs ( jr PPO1 26,27 , Md PPO1 16,24 Ab PPO3 28 and Ab PPO4 29 ) and COs ( Ib CO 22 , Vv PPO 23 and cg AUS1 25 ) revealed no considerable differences (Table S1)

Oral administration of high-dose vitamin B 12 (1 to 2 mg daily) is as effective as intramuscular administration for correcting anemia and neurologic symptoms

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