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This dysfunction can be triggered by intrinsic host factors, such as autoimmune diseases ( Figure 1 Among these risk factors, infectious pathogens play a significant role as environmental risk factors in SZ

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It is involved in mitochondrial function, connective tissue enzymes, neurotransmitter synthesis, and antioxidant defenses

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Finally, the very probable involvement of gut microbiota in the pathogenesis of this psychiatric disorder opens promising approaches to modulate the gut microbiota and the MGB axis, including dietary interventions, the use of pre-, pro- and postbiotics and other therapeutic approaches like FMT and other lifestyle interventions