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The disease is caused by mutations in the GLA gene, located on the X-chromosome and encoding the enzyme -galactosidase A (-Gal A), which catalyzes the hydrolysis of globotriaosylceramide (Gb3) [4]

Although once avoided in congestive heart failure, current evidence supports its safety and potential benefit in stable CHF, with discontinuation advised during acute decompensation (Wang et al., 2021

Studies show that these proteins stop degradation

doi: 10.1016/bs.vh.2022.09.002 81 IghodaroOMAkinloyeOA