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Primary carnitine deficiency (PCD) is a rare autosomal recessive disorder of fatty acid oxidation caused by deficiency of plasma membrane carnitine transport resulting from impairment in the plasma membrane OCTN2 carnitine transporter

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The underlying mechanisms most likely involve the reduction of ERS-induced apoptosis by suppressing CHOP expression

[7]: Quetiapine (300-600 mg day): Seven out of seven studies positive, N = 2,152, SDM: 0.35 (0.23-0.47), Olanzapine: four RCTs, N = 732 (SDM: 0.35 (0.17-0.54), Lurasidone: Four RCTs, N = 1,029, SDM: 0.29 (0.14-0.45) and Cariprazine: Four RCTs, N = 997, SDM: 0.23 (0.06-0.39)

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