However, heightened levels of ROS, which overpower cellular antioxidant and repair capacities, can trigger oxidative stress in cells, directly causing oxidative damage to all biomolecules within the cellular environment (including proteins, lipids, and DNA), and thus contribute to the development of aging and related diseases (Dizdaroglu and Jaruga, 2012
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However, a subset of EVs can evade degradative pathways and enter recycling or transcytotic routes 157,163
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2026 Mar 11;148(9):10225-10240