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Separate human evidence from preclinical or anecdotal claims

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With topical use, rash and blistering have been reported with 5% alpha-lipoic acid creams, including a case in an 86-year-old woman who applied a 5% alpha-lipoic acid cream to her lower leg and thigh for chronic venous insufficiency [32], and cases of severe facial skin irritation from skin-aging creams containing 5% alpha-lipoic acid [33][34]

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