494,495 Both nickel and lower pH activate Hp NikR to bind to the ureA promoter with similar affinities and locations on the DNA, 495 but the mechanism of allosteric regulation of DNA binding by acidity remains unknown
The diagnostic process typically involves: Clinical history taking, focusing on symptoms (fatigue, neurological changes, dietary habits) Physical examination for signs of anaemia or neurological impairment Blood tests including full blood count, serum B12, and often folate levels Additional investigations such as intrinsic factor antibodies or parietal cell antibodies if pernicious anaemia is suspected For borderline results, additional tests like holotranscobalamin (active B12) may be considered NICE guidance recommends that treatment should commence based on clinical presentation if neurological symptoms are present, without waiting for laboratory confirmation, as delays can result in irreversible nerve damage
For informational and research purposes only
S2CID 36014480
Cell Mol Life Sci 57:15081516
Label Warnings Not a sole source of nutrition and should be consumed with a nutritious diet.
