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The global deletion of Gpx4 in mice causes early embryonic lethality, and its knockout in hepatocytes or neurons leads to perinatal or postnatal death [24]

Within activated macrophages there are distinct changes in TCA cycle activity that lead to the accumulation of TCA cycle intermediates, particularly fumarate and itaconate

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Comment: Some commenters supported CMS' proposed approach to determine the proportion of the performance year affected by the EUC due to cyberattack using the start and end dates provided on the ACO's EUC Exception application or defaulting to a 90-day duration when no end date is included, unless the start date is less than 90 days from the end of the performance year

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